WormFlux: mechanistic analysis of C. elegans metabolism

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	2.3.1.168
Name .....................................................	:	Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, etc.Dihydrolipoyl transacylase, Enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase, 2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K09699E2.3.1.168 bkdB; 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]
Genes .....................................................	:	dbt-1
Localization .....................................................	:	Mitochondria
Other associations .....................................................	:	See reaction table below.

External links

KEGG

BRENDA

Reactions

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RMC0133Name: branched-chain 2-oxo acid dehydrogenase Type: Regular Location: Mitochondria KEGG ID: NA click to see details on this item	1.2.4.4Name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Other names: 2-oxoisocaproate dehydrogenase, 2-oxoisovalerate (lipoate) dehydrogenase, 3-methyl-2-oxobutanoate dehydrogenase (lipoamide), 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating), alpha-keto-alpha-methylvalerate dehydrogenase, alpha-ketoisocaproate dehydrogenase, alpha-ketoisocaproic dehydrogenase, alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase, alpha-ketoisovalerate dehydrogenase, alpha-oxoisocaproate dehydrogenase, BCKDH, BCOAD, branched chain keto acid dehydrogenase, branched-chain (-2-oxoacid) dehydrogenase (BCD), branched-chain 2-keto acid dehydrogenase, branched-chain 2-oxo acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase, branched-chain alpha-oxo acid dehydrogenase, branched-chain keto acid dehydrogenase, branched-chain ketoacid dehydrogenase, dehydrogenase, 2-oxoisovalerate (lipoate), dehydrogenase, branched chain alpha-keto acid click to see details on this item 1.8.1.4Name: dihydrolipoyl dehydrogenase Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase click to see details on this item 2.3.1.168Name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase Other names: dihydrolipoyl transacylase, enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase, 2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase click to see details on this item	[m] : 2obutName: 2-Oxobutanoate Formula: C4H5O3 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + ppcoaName: Propanoyl-CoA Formula: C24H36N7O17P3S Charge: -4 click to see details on this item	[(bckd-1A \| Y43F4A.4) & bckd-1B] & dld-1 & dbt-1	Propionate degradation
RMC0011Name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial Type: Regular Location: Mitochondria KEGG ID: R07601;R07602;R07618;R04097 click to see details on this item	1.2.4.4Name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Other names: 2-oxoisocaproate dehydrogenase, 2-oxoisovalerate (lipoate) dehydrogenase, 3-methyl-2-oxobutanoate dehydrogenase (lipoamide), 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating), alpha-keto-alpha-methylvalerate dehydrogenase, alpha-ketoisocaproate dehydrogenase, alpha-ketoisocaproic dehydrogenase, alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase, alpha-ketoisovalerate dehydrogenase, alpha-oxoisocaproate dehydrogenase, BCKDH, BCOAD, branched chain keto acid dehydrogenase, branched-chain (-2-oxoacid) dehydrogenase (BCD), branched-chain 2-keto acid dehydrogenase, branched-chain 2-oxo acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase, branched-chain alpha-oxo acid dehydrogenase, branched-chain keto acid dehydrogenase, branched-chain ketoacid dehydrogenase, dehydrogenase, 2-oxoisovalerate (lipoate), dehydrogenase, branched chain alpha-keto acid click to see details on this item 1.8.1.4Name: dihydrolipoyl dehydrogenase Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase click to see details on this item 2.3.1.168Name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase Other names: dihydrolipoyl transacylase, enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase, 2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase click to see details on this item	[m] : 4mopName: 4-Methyl-2-oxopentanoate Formula: C6H9O3 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + ivcoaName: Isovaleryl-CoA Formula: C26H40N7O17P3S Charge: -4 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	[(bckd-1A \| Y43F4A.4) & bckd-1B] & dld-1 & dbt-1	Leucine degradation
RMC0012Name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial Type: Regular Location: Mitochondria KEGG ID: R07599;R07600;R07618;R02662 click to see details on this item	1.2.4.4Name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Other names: 2-oxoisocaproate dehydrogenase, 2-oxoisovalerate (lipoate) dehydrogenase, 3-methyl-2-oxobutanoate dehydrogenase (lipoamide), 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating), alpha-keto-alpha-methylvalerate dehydrogenase, alpha-ketoisocaproate dehydrogenase, alpha-ketoisocaproic dehydrogenase, alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase, alpha-ketoisovalerate dehydrogenase, alpha-oxoisocaproate dehydrogenase, BCKDH, BCOAD, branched chain keto acid dehydrogenase, branched-chain (-2-oxoacid) dehydrogenase (BCD), branched-chain 2-keto acid dehydrogenase, branched-chain 2-oxo acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase, branched-chain alpha-oxo acid dehydrogenase, branched-chain keto acid dehydrogenase, branched-chain ketoacid dehydrogenase, dehydrogenase, 2-oxoisovalerate (lipoate), dehydrogenase, branched chain alpha-keto acid click to see details on this item 1.8.1.4Name: dihydrolipoyl dehydrogenase Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase click to see details on this item 2.3.1.168Name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase Other names: dihydrolipoyl transacylase, enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase, 2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase click to see details on this item	[m] : 3mobName: 3-Methyl-2-oxobutanoate Formula: C5H7O3 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + ibcoaName: Isobutyryl-CoA Formula: C25H38N7O17P3S Charge: -4 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	[(bckd-1A \| Y43F4A.4) & bckd-1B] & dld-1 & dbt-1	Valine degradation
RMC0013Name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial Type: Regular Location: Mitochondria KEGG ID: R07603;R07604;R07618;R03174 click to see details on this item	1.2.4.4Name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Other names: 2-oxoisocaproate dehydrogenase, 2-oxoisovalerate (lipoate) dehydrogenase, 3-methyl-2-oxobutanoate dehydrogenase (lipoamide), 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating), alpha-keto-alpha-methylvalerate dehydrogenase, alpha-ketoisocaproate dehydrogenase, alpha-ketoisocaproic dehydrogenase, alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase, alpha-ketoisovalerate dehydrogenase, alpha-oxoisocaproate dehydrogenase, BCKDH, BCOAD, branched chain keto acid dehydrogenase, branched-chain (-2-oxoacid) dehydrogenase (BCD), branched-chain 2-keto acid dehydrogenase, branched-chain 2-oxo acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase, branched-chain alpha-oxo acid dehydrogenase, branched-chain keto acid dehydrogenase, branched-chain ketoacid dehydrogenase, dehydrogenase, 2-oxoisovalerate (lipoate), dehydrogenase, branched chain alpha-keto acid click to see details on this item 1.8.1.4Name: dihydrolipoyl dehydrogenase Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase click to see details on this item 2.3.1.168Name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase Other names: dihydrolipoyl transacylase, enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase, 2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase click to see details on this item	[m] : 3mopName: (S)-3-Methyl-2-oxopentanoate Formula: C6H9O3 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	2mbcoaName: 2-Methylbutanoyl-CoA Formula: C26H40N7O17P3S Charge: -4 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	[(bckd-1A \| Y43F4A.4) & bckd-1B] & dld-1 & dbt-1	Isoleucine degradation

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