Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	ahcys
Name .....................................................	:	S-Adenosyl-L-homocysteine, etc.S-Adenosylhomocysteine
Model ID .....................................................	:	C00021
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00021
Formula .....................................................	:	C14H20N6O5S
Charge .....................................................	:	0
Localization .....................................................	:	Extracellular, Cytosol, Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	ahcys
Other associations .....................................................	:	See reaction table below (19 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Represented in 6 maps... Glycerophospholipid metabolism (c) Histidine degradation (c) Methionine / S-adenosylmethionine cycle (c) Nicotinate and nicotinamide metabolism (c) Selenocompound metabolism (c) Ubiquinone metabolism (m)   Go to map

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0177Name: Protein-lysine methylase Type: Regular Location: Cytosol KEGG ID: R03875;R04866;R04867 click to see details on this item	2.1.1.43Name: histone-lysine N-methyltransferase Other names: protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase click to see details on this item	[c] : peplysName: Peptidyl-L-lysine Formula: XC6H13N2O Charge: 1 click to see details on this item + (3) ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item		peptmelysName: Protein N6,N6,N6-trimethyl-L-lysine Formula: XC9H19N2O Charge: 1 click to see details on this item + (3) ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item	[set-16 | lin-59 | (met-1 | set-12) | set-2 | met-2 | set-11 | mes-2 | set-23 | (dot-1.1 | dot-1.2 | dot-1.3 | dot-1.4 | dot-1.5) | set-4 | set-1] | [set-13 | set-15 | set-21 | set-32 | set-33 | set-6]	Carnitine biosynthesis
RC00192Name: S-Adenosyl-L-homocysteine hydrolase Type: Regular Location: Cytosol KEGG ID: R00192 click to see details on this item	3.3.1.1Name: adenosylhomocysteinase Other names: S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase (ambiguous), adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase click to see details on this item	[c] : ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		adnName: Adenosine Formula: C10H13N5O4 Charge: 0 click to see details on this item + hcys-LName: L-Homocysteine Formula: C4H9NO2S Charge: 0 click to see details on this item	ahcy-1	Methionine / S-adenosylmethionine cycle
RC00650Name: S-Adenosyl-L-methionine:L-homocysteine S-methyltransferase Type: Regular Location: Cytosol KEGG ID: R00650 click to see details on this item	2.1.1.10Name: homocysteine S-methyltransferase Other names: S-adenosylmethionine homocysteine transmethylase, S-methylmethionine homocysteine transmethylase, adenosylmethionine transmethylase, methylmethionine:homocysteine methyltransferase, adenosylmethionine:homocysteine methyltransferase, homocysteine methylase, homocysteine methyltransferase, homocysteine transmethylase, L-homocysteine S-methyltransferase, S-adenosyl-L-methionine:L-homocysteine methyltransferase, S-adenosylmethionine-homocysteine transmethylase, S-adenosylmethionine:homocysteine methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + hcys-LName: L-Homocysteine Formula: C4H9NO2S Charge: 0 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + met-LName: L-Methionine Formula: C5H11NO2S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	T13G4.4	Methionine / S-adenosylmethionine cycle
RC02037Name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Type: Regular Location: Cytosol KEGG ID: R02037 click to see details on this item	2.1.1.103Name: phosphoethanolamine N-methyltransferase Other names: phosphoethanolamine methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + ethampName: Ethanolamine phosphate Formula: C2H7NO4P Charge: -1 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + methampName: N-Methylethanolamine phosphate Formula: C3H9NO4P Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	pmt-1	Glycerophospholipid metabolism
RCC0021Name: S-Adenosyl-L-methionine:methylethanolamine-phosphate N-methyltransferase Type: Regular Location: Cytosol KEGG ID: R06868;R06869 click to see details on this item	2.1.1.103Name: phosphoethanolamine N-methyltransferase Other names: phosphoethanolamine methyltransferase click to see details on this item	[c] : (2) ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + methampName: N-Methylethanolamine phosphate Formula: C3H9NO4P Charge: -1 click to see details on this item		(2) ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + cholpName: Choline phosphate Formula: C5H13NO4P Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item	pmt-2	Glycerophospholipid metabolism
RC03875Name: S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase Type: Regular Location: Cytosol KEGG ID: R03875 click to see details on this item	2.1.1.43Name: histone-lysine N-methyltransferase Other names: protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + NlysName: Histone-L-Lysine Formula: XC6H13N2O Charge: 1 click to see details on this item		NmelysName: Histone N6-methyl-L-lysine Formula: XC7H15N2O Charge: 1 click to see details on this item + ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	[set-16 | lin-59 | (met-1 | set-12) | set-2 | met-2 | set-11 | mes-2 | set-23 | (dot-1.1 | dot-1.2 | dot-1.3 | dot-1.4 | dot-1.5) | set-4 | set-1] | [set-13 | set-15 | set-21 | set-32 | set-33 | set-6]	Histone modification
RC04866Name: S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase (acting on monomethylated residues) Type: Regular Location: Cytosol KEGG ID: R04866 click to see details on this item	2.1.1.43Name: histone-lysine N-methyltransferase Other names: protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase click to see details on this item	[c] : NmelysName: Histone N6-methyl-L-lysine Formula: XC7H15N2O Charge: 1 click to see details on this item + ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item		NdmelysName: Histone N6,N6-dimethyl-L-lysine Formula: XC8H17N2O Charge: 1 click to see details on this item + ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	[set-16 | lin-59 | (met-1 | set-12) | set-2 | met-2 | set-11 | mes-2 | set-23 | (dot-1.1 | dot-1.2 | dot-1.3 | dot-1.4 | dot-1.5) | set-4 | set-1] | [set-13 | set-15 | set-21 | set-32 | set-33 | set-6]	Histone modification
RC04867Name: S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase (acting on dimethylated residues) Type: Regular Location: Cytosol KEGG ID: R04867 click to see details on this item	2.1.1.43Name: histone-lysine N-methyltransferase Other names: protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase click to see details on this item	[c] : NdmelysName: Histone N6,N6-dimethyl-L-lysine Formula: XC8H17N2O Charge: 1 click to see details on this item + ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item		NtmelysName: Histone N6,N6,N6-trimethyl-L-lysine Formula: XC9H19N2O Charge: 1 click to see details on this item + ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	[set-16 | lin-59 | (met-1 | set-12) | set-2 | met-2 | set-11 | mes-2 | set-23 | (dot-1.1 | dot-1.2 | dot-1.3 | dot-1.4 | dot-1.5) | set-4 | set-1] | [set-13 | set-15 | set-21 | set-32 | set-33 | set-6]	Histone modification
RC01269Name: S-Adenosyl-L-methionine:nicotinamide N-methyltransferase Type: Regular Location: Cytosol KEGG ID: R01269 click to see details on this item	2.1.1.1Name: nicotinamide N-methyltransferase Other names: nicotinamide methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + 1mncamName: 1-Methylnicotinamide Formula: C7H9N2O Charge: 1 click to see details on this item	anmt-1 | anmt-3	Nicotinate and nicotinamide metabolism
RC10306Name: S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] methyltransferase Type: Regular Location: Cytosol KEGG ID: R10306 click to see details on this item	2.1.1.98Name: diphthine synthase Other names: S-adenosyl-L-methionine:elongation factor 2 methyltransferase, diphthine methyltransferase, S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase click to see details on this item	[c] : (3) ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + caphisName: Peptide 2-(3-carboxy-3-aminopropyl)-L-histidine Formula: C11H15N5O4R2 Charge: 0 click to see details on this item		(3) ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + pdiphtName: Peptide diphthine Formula: C14H21N5O4R2 Charge: 0 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item	B0491.7	Miscellaneous
RC09371Name: S-adenosyl-L-methionine:hydrogen-selenide Se-methyltransferase Type: Regular Location: Cytosol KEGG ID: R09371 click to see details on this item	2.1.1.-Name: s-adenosyl-L-methionine:hydrogen-selenide Se-methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + selnName: Selenide Formula: HSe Charge: -1 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + metselName: Methylselenol Formula: CH3Se Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	nsun-5 | mett-10	Selenocompound metabolism
RC04496Name: S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase Type: Regular Location: Cytosol KEGG ID: R04496 click to see details on this item	2.1.1.100Name: protein-S-isoprenylcysteine O-methyltransferase Other names: farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, protein C-terminal farnesylcysteine O-methyltransferase, farnesylated protein C-terminal O-methyltransferase, isoprenylated protein methyltransferase, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, prenylcysteine carboxylmethyltransferase [misleading], prenylcysteine carboxymethyltransferase [misleading], prenylcysteine methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + protSfarCName: Protein C-terminal S-farnesyl-L-cysteine Formula: C20H33N2O3SR(C2H2NOR)n Charge: 0 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + protSfarCmetName: Protein C-terminal S-farnesyl-L-cysteine methyl ester Formula: C21H35N2O3SR(C2H2NOR)n Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	icmt-1 | M01E11.1	Miscellaneous
RCC0034Name: S-Adenosyl-L-methionine:protein-C-terminal-S-geranylgeranyl-L-cysteine O-methyltransferase Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	2.1.1.100Name: protein-S-isoprenylcysteine O-methyltransferase Other names: farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, protein C-terminal farnesylcysteine O-methyltransferase, farnesylated protein C-terminal O-methyltransferase, isoprenylated protein methyltransferase, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, prenylcysteine carboxylmethyltransferase [misleading], prenylcysteine carboxymethyltransferase [misleading], prenylcysteine methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + protSgerCName: Protein C-terminal S-geranylgeranyl-L-cysteine Formula: C25H41N2O3SR(C2H2NOR)n Charge: 0 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + protSgerCmetName: Protein C-terminal S-geranylgeranyl-L-cysteine methyl ester Formula: C26H43N2O3SR(C2H2NOR)n Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	icmt-1 | M01E11.1	Miscellaneous
RM08771Name: dihydroxydecaprenylbenzoate methyltransferase Type: Regular Location: Mitochondria KEGG ID: R08771 click to see details on this item	2.1.1.114Name: polyprenyldihydroxybenzoate methyltransferase Other names: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, dihydroxyhexaprenylbenzoate methyltransferase, COQ3 (gene name), Coq3 O-methyltransferase, DHHB O-methyltransferase click to see details on this item	[m] : 3npdhbName: 3-nonaprenyl-4,5-dihydroxybenzoate Formula: C52H77O4 Charge: -1 click to see details on this item + ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item		3npdhb_meName: 3-nonaprenyl-4-hydroxy-5-methoxybenzoate Formula: C53H79O4 Charge: -1 click to see details on this item + ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	coq-3	Ubiquinone metabolism
RM08774Name: Ubiquinone biosynthesis methyltransferase COQ5 Type: Regular Location: Mitochondria KEGG ID: R08774 click to see details on this item	2.1.1.201Name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase Other names: ubiE (gene name, ambiguous) click to see details on this item	[m] : 2np6mobqName: 2-nonaprenyl-6-methoxy-1,4-benzoquinone Formula: C52H78O3 Charge: 0 click to see details on this item + ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item		2np6mobq_meName: 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone Formula: C53H80O3 Charge: 0 click to see details on this item + ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	coq-5	Ubiquinone metabolism
RM08781Name: methyltransferase COQ3 Type: Regular Location: Mitochondria KEGG ID: R08781 click to see details on this item	2.1.1.114Name: polyprenyldihydroxybenzoate methyltransferase Other names: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, dihydroxyhexaprenylbenzoate methyltransferase, COQ3 (gene name), Coq3 O-methyltransferase, DHHB O-methyltransferase click to see details on this item	[m] : 2npmhobqName: 2-Decaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone Formula: C53H80O4 Charge: 0 click to see details on this item + ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + q9Name: Ubiquinone-9 Formula: C54H82O4 Charge: 0 click to see details on this item	coq-3	Ubiquinone metabolism
TCE5311Name: S-Adenosyl-L-homocysteine transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item[e]		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item[c]	Not determined	Transport
TCM1091Name: S-Adenosyl-L-homocysteine transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item[c]		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item[m]	Not determined	Transport
EX00021Name: S-Adenosyl-L-homocysteine exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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