Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	mev-R
Name .....................................................	:	(R)-Mevalonate, etc.Mevalonic acid, 3,5-Dihydroxy-3-methylvaleric acid
Model ID .....................................................	:	C00418
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00418
Formula .....................................................	:	C6H11O4
Charge .....................................................	:	-1
Localization .....................................................	:	Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	mev-R
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Mevalonate metabolism (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC02082Name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Type: Regular Location: Cytosol KEGG ID: R02082 click to see details on this item	1.1.1.34Name: hydroxymethylglutaryl-CoA reductase (NADPH) Other names: hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), S-3-hydroxy-3-methylglutaryl-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA), 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-CoA reductase (NADPH2) click to see details on this item	[c] : (2) hName: H+ Formula: H Charge: 1 click to see details on this item + hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + mev-RName: (R)-Mevalonate Formula: C6H11O4 Charge: -1 click to see details on this item + (2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	hmgr-1	Mevalonate metabolism
RC02245Name: ATP:(R)-mevalonate 5-phosphotransferase Type: Regular Location: Cytosol KEGG ID: R02245 click to see details on this item	2.7.1.36Name: mevalonate kinase Other names: mevalonate kinase (phosphorylating), mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, mevalonate 5-phosphotransferase , MVA kinase, ATP:mevalonate 5-phosphotransferase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + mev-RName: (R)-Mevalonate Formula: C6H11O4 Charge: -1 click to see details on this item		5pmevName: (R)-5-Phosphomevalonate Formula: C6H10O7P Charge: -3 click to see details on this item + adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	mvk-1	Mevalonate metabolism

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