Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	5mthf
Name .....................................................	:	5-Methyltetrahydrofolate
Model ID .....................................................	:	C00440
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00440
Formula .....................................................	:	C20H24N7O6
Charge .....................................................	:	-1
Localization .....................................................	:	Extracellular, Cytosol, Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	5mthf
Other associations .....................................................	:	See reaction table below (6 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Folate cycle (c), Methionine / S-adenosylmethionine cycle (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00946Name: methionine synthase Type: Regular Location: Cytosol KEGG ID: R00946;R05182 click to see details on this item	2.1.1.13Name: methionine synthase Other names: 5-methyltetrahydrofolate---homocysteine S-methyltransferase, 5-methyltetrahydrofolate---homocysteine transmethylase, N-methyltetrahydrofolate:L-homocysteine methyltransferase, N5-methyltetrahydrofolate methyltransferase, N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase, N5-methyltetrahydrofolic---homocysteine vitamin B12 transmethylase, B12 N5-methyltetrahydrofolate homocysteine methyltransferase, methyltetrahydrofolate---homocysteine vitamin B12 methyltransferase, tetrahydrofolate methyltransferase, tetrahydropteroylglutamate methyltransferase, tetrahydropteroylglutamic methyltransferase, vitamin B12 methyltransferase, cobalamin-dependent methionine synthase, methionine synthase (cobalamin-dependent), MetH click to see details on this item	[c] : 5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item + hcys-LName: L-Homocysteine Formula: C4H9NO2S Charge: 0 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + met-LName: L-Methionine Formula: C5H11NO2S Charge: 0 click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate" Formula: C19H21N7O6 Charge: -2 click to see details on this item	metr-1 & mtrr-1	Folate cycle
RC01224Name: 5-methyltetrahydrofolate:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01224 click to see details on this item	1.5.1.20Name: methylenetetrahydrofolate reductase [NAD(P)H] Other names: methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-CH2-H4folate reductase, methylenetetrahydrofolate reductase (NADPH2), 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, 5,10-methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase, N5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydropteroylglutamate reductase, N5,N10-methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect), 5,10-methylenetetrahydrofolate reductase (FADH2), MetF, methylenetetrahydrofolate reductase (NADPH), 5-methyltetrahydrofolate:NADP+ oxidoreductase click to see details on this item	[c] : (2) hName: H+ Formula: H Charge: 1 click to see details on this item + mlthfName: "5,10-Methylenetetrahydrofolate" Formula: C20H21N7O6 Charge: -2 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	mthf-1	Folate cycle
RC07168Name: 5-methyltetrahydrofolate:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R07168 click to see details on this item	1.5.1.20Name: methylenetetrahydrofolate reductase [NAD(P)H] Other names: methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-CH2-H4folate reductase, methylenetetrahydrofolate reductase (NADPH2), 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, 5,10-methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase, N5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydropteroylglutamate reductase, N5,N10-methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect), 5,10-methylenetetrahydrofolate reductase (FADH2), MetF, methylenetetrahydrofolate reductase (NADPH), 5-methyltetrahydrofolate:NADP+ oxidoreductase click to see details on this item	[c] : (2) hName: H+ Formula: H Charge: 1 click to see details on this item + mlthfName: "5,10-Methylenetetrahydrofolate" Formula: C20H21N7O6 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	mthf-1	Folate cycle
TCE0533Name: 5-Methyltetrahydrofolate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item[e]		5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item[c]	Not determined	Transport
TCM1035Name: 5-Methyltetrahydrofolate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item[c]		5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item[m]	Not determined	Transport
EX00440Name: 5-Methyltetrahydrofolate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item[e]			Not applicable	Exchange with the environment

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