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Use wild characters " ? " and " * " for efficient search:
  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
Network Biomass WormPaths
FBAFlux Balance Analysis PEAPathway Enrichment Analysis
Enzyme Overview
Enzyme (?) Identification in Enzyme Commission (EC) numbering system. ..................................................... : 1.5.1.3
Name ..................................................... : Dihydrofolate reductase, etc.Tetrahydrofolate dehydrogenase, DHFR, Pteridine reductase:dihydrofolate reductase, Dihydrofolate reductase:thymidylate synthase, Thymidylate synthetase-dihydrofolate reductase, Folic acid reductase, Folic reductase, Dihydrofolic acid reductase, Dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. ..................................................... : K00287folA; dihydrofolate reductase [EC:1.5.1.3]
Genes ..................................................... : dhfr-1
Localization ..................................................... : Cytosol
Other associations ..................................................... : See reaction table below.
Reactions
ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses. 		Pathway
RC00936Name: 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Type: Regular
Location: Cytosol
KEGG ID: R00936

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1.5.1.3Name: dihydrofolate reductase
Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase

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[c] : dhfName: "7,8-Dihydrofolate"
Formula: C19H19N7O6
Charge: -2




click to see details on this item + hName: H+
Formula: H
Charge: 1




click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced
Formula: C21H27N7O14P2
Charge: -2




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nadName: Nicotinamide adenine dinucleotide
Formula: C21H26N7O14P2
Charge: -1




click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate"
Formula: C19H21N7O6
Charge: -2




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dhfr-1
Folate cycle
RC00939Name: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Type: Regular
Location: Cytosol
KEGG ID: R00939

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1.5.1.3Name: dihydrofolate reductase
Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase

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[c] : dhfName: "7,8-Dihydrofolate"
Formula: C19H19N7O6
Charge: -2




click to see details on this item + hName: H+
Formula: H
Charge: 1




click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced
Formula: C21H26N7O17P3
Charge: -4




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nadpName: Nicotinamide adenine dinucleotide phosphate
Formula: C21H25N7O17P3
Charge: -3




click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate"
Formula: C19H21N7O6
Charge: -2




click to see details on this item
dhfr-1
Folate cycle
RC02235Name: dihydrofolate:NAD+ oxidoreductase
Type: Regular
Location: Cytosol
KEGG ID: R02235

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1.5.1.3Name: dihydrofolate reductase
Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase

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[c] : folName: Folate
Formula: C19H18N7O6
Charge: -1




click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced
Formula: C21H27N7O14P2
Charge: -2




click to see details on this item
dhfName: "7,8-Dihydrofolate"
Formula: C19H19N7O6
Charge: -2




click to see details on this item + nadName: Nicotinamide adenine dinucleotide
Formula: C21H26N7O14P2
Charge: -1




click to see details on this item
dhfr-1
Folate cycle
RC02236Name: dihydrofolate:NADP+ oxidoreductase
Type: Regular
Location: Cytosol
KEGG ID: R02236

click to see details on this item
1.5.1.3Name: dihydrofolate reductase
Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase

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[c] : folName: Folate
Formula: C19H18N7O6
Charge: -1




click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced
Formula: C21H26N7O17P3
Charge: -4




click to see details on this item
dhfName: "7,8-Dihydrofolate"
Formula: C19H19N7O6
Charge: -2




click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate
Formula: C21H25N7O17P3
Charge: -3




click to see details on this item
dhfr-1
Folate cycle
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