WormFlux: mechanistic analysis of C. elegans metabolism

Metabolite Overview

Abbreviation .....................................................	:	udpglcur
Name .....................................................	:	UDP-D-glucuronate, etc.UDP-glucuronate, UDPglucuronate, UDP-alpha-D-glucuronate
Model ID .....................................................	:	C00167
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00167
Formula .....................................................	:	C15H19N2O18P2
Charge .....................................................	:	-3
Localization .....................................................	:	Extracellular, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	udpglcur
Other associations .....................................................	:	See reaction table below (8 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Amino sugar and nucleotide sugar metabolism (c), Pentose and glucuronate interconversions (c), Retinol metabolism (c)

iCEL1314

Comments

ERROR

Reactions

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00286Name: UDP-glucose:NAD+ 6-oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00286 click to see details on this item	1.1.1.22Name: UDP-glucose 6-dehydrogenase Other names: UDP-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, UDPG dehydrogenase, UDPG:NAD oxidoreductase, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-glucose:NAD+ oxidoreductase, uridine diphosphate glucose dehydrogenase, UDP-D-glucose dehydrogenase, uridine diphosphate D-glucose dehydrogenase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + (2) nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + udpgName: UDPglucose Formula: C15H22N2O17P2 Charge: -2 click to see details on this item	(3) hName: H+ Formula: H Charge: 1 click to see details on this item + (2) nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item	sqv-4	Amino sugar and nucleotide sugar metabolism
RCC0053Name: UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific); beta-D-glucuronoside glucuronosohydrolase Type: Regular Location: Cytosol KEGG ID: R01383;R01478 click to see details on this item	2.4.1.17Name: glucuronosyltransferase Other names: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase click to see details on this item 3.2.1.31Name: beta-glucuronidase Other names: beta-glucuronide glucuronohydrolase glucuronidase, exo-beta-D-glucuronidase, ketodase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item	glcurName: D-Glucuronate Formula: C6H9O7 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + udpName: UDP Formula: C9H11N2O12P2 Charge: -3 click to see details on this item	(C03A7.13 \| C55H1.1 \| F10D2.8 \| F54C1.1 \| H23N18.4 \| K04A8.10 \| ugt-1 \| ugt-10 \| ugt-11 \| ugt-12 \| ugt-13 \| ugt-14 \| ugt-15 \| ugt-16 \| ugt-17 \| ugt-18 \| ugt-19 \| ugt-2 \| ugt-20 \| ugt-21 \| ugt-22 \| ugt-23 \| ugt-24 \| ugt-25 \| ugt-26 \| ugt-27 \| ugt-29 \| ugt-3 \| ugt-30 \| ugt-31 \| ugt-32 \| ugt-33 \| ugt-34 \| ugt-35 \| ugt-36 \| ugt-37 \| ugt-38 \| ugt-39 \| ugt-4 \| ugt-40 \| ugt-41 \| ugt-42 \| ugt-43 \| ugt-44 \| ugt-45 \| ugt-46 \| ugt-47 \| ugt-48 \| ugt-49 \| ugt-5 \| ugt-50 \| ugt-51 \| ugt-52 \| ugt-53 \| ugt-54 \| ugt-55 \| ugt-56 \| ugt-58 \| ugt-59 \| ugt-6 \| ugt-60 \| ugt-61 \| ugt-62 \| ugt-63 \| ugt-64 \| ugt-65 \| ugt-7 \| ugt-8 \| ugt-9) & (Y105E8B.9)	Pentose and glucuronate interconversions
RC02389Name: UDP-glucuronate-bilirubin glucuronyltransferase Type: Regular Location: Cytosol KEGG ID: R02389 click to see details on this item	2.4.1.17Name: glucuronosyltransferase Other names: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase click to see details on this item	[c] : (2.0) udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item + bilirubName: Bilirubin Formula: C33H34N4O6 Charge: -2 click to see details on this item	(2.0) udpName: UDP Formula: C9H11N2O12P2 Charge: -3 click to see details on this item + bildglcurName: Bilirubin beta-diglucuronide Formula: C45H50N4O18 Charge: -2 click to see details on this item	C03A7.13 \| C55H1.1 \| F10D2.8 \| F54C1.1 \| H23N18.4 \| K04A8.10 \| ugt-1 \| ugt-10 \| ugt-11 \| ugt-12 \| ugt-13 \| ugt-14 \| ugt-15 \| ugt-16 \| ugt-17 \| ugt-18 \| ugt-19 \| ugt-2 \| ugt-20 \| ugt-21 \| ugt-22 \| ugt-23 \| ugt-24 \| ugt-25 \| ugt-26 \| ugt-27 \| ugt-29 \| ugt-3 \| ugt-30 \| ugt-31 \| ugt-32 \| ugt-33 \| ugt-34 \| ugt-35 \| ugt-36 \| ugt-37 \| ugt-38 \| ugt-39 \| ugt-4 \| ugt-40 \| ugt-41 \| ugt-42 \| ugt-43 \| ugt-44 \| ugt-45 \| ugt-46 \| ugt-47 \| ugt-48 \| ugt-49 \| ugt-5 \| ugt-50 \| ugt-51 \| ugt-52 \| ugt-53 \| ugt-54 \| ugt-55 \| ugt-56 \| ugt-58 \| ugt-59 \| ugt-6 \| ugt-60 \| ugt-61 \| ugt-62 \| ugt-63 \| ugt-64 \| ugt-65 \| ugt-7 \| ugt-8 \| ugt-9	Miscellaneous
RC02902Name: UDP-glucuronate-retinol glucuronyltransferase Type: Regular Location: Cytosol KEGG ID: R02902 click to see details on this item	2.4.1.17Name: glucuronosyltransferase Other names: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase click to see details on this item	[c] : retnName: Retinoate Formula: C20H27O2 Charge: -1 click to see details on this item + udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item	retnglcName: retinoyl glucuronide Formula: C26H35O8 Charge: -1 click to see details on this item + udpName: UDP Formula: C9H11N2O12P2 Charge: -3 click to see details on this item	C03A7.13 \| C55H1.1 \| F10D2.8 \| F54C1.1 \| H23N18.4 \| K04A8.10 \| ugt-1 \| ugt-10 \| ugt-11 \| ugt-12 \| ugt-13 \| ugt-14 \| ugt-15 \| ugt-16 \| ugt-17 \| ugt-18 \| ugt-19 \| ugt-2 \| ugt-20 \| ugt-21 \| ugt-22 \| ugt-23 \| ugt-24 \| ugt-25 \| ugt-26 \| ugt-27 \| ugt-29 \| ugt-3 \| ugt-30 \| ugt-31 \| ugt-32 \| ugt-33 \| ugt-34 \| ugt-35 \| ugt-36 \| ugt-37 \| ugt-38 \| ugt-39 \| ugt-4 \| ugt-40 \| ugt-41 \| ugt-42 \| ugt-43 \| ugt-44 \| ugt-45 \| ugt-46 \| ugt-47 \| ugt-48 \| ugt-49 \| ugt-5 \| ugt-50 \| ugt-51 \| ugt-52 \| ugt-53 \| ugt-54 \| ugt-55 \| ugt-56 \| ugt-58 \| ugt-59 \| ugt-6 \| ugt-60 \| ugt-61 \| ugt-62 \| ugt-63 \| ugt-64 \| ugt-65 \| ugt-7 \| ugt-8 \| ugt-9	Retinol metabolism
RC01384Name: UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming) Type: Regular Location: Cytosol KEGG ID: R01384 click to see details on this item	4.1.1.35Name: UDP-glucuronate decarboxylase Other names: uridine-diphosphoglucuronate decarboxylase, UDP-D-glucuronate carboxy-lyase click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item	co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + udpxylName: UDP-D-xylose Formula: C14H20N2O16P2 Charge: -2 click to see details on this item	sqv-1	Amino sugar and nucleotide sugar metabolism
RC02478Name: UDP-glucuronate-androsterone glucuronyltransferase Type: Regular Location: Cytosol KEGG ID: R02478 click to see details on this item	2.4.1.17Name: glucuronosyltransferase Other names: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase click to see details on this item	[c] : andrstrnName: Androsterone Formula: C19H30O2 Charge: 0 click to see details on this item + udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item	andrstrnglcName: androsterone glucuronide Formula: C25H38O8 Charge: 0 click to see details on this item + udpName: UDP Formula: C9H11N2O12P2 Charge: -3 click to see details on this item	C03A7.13 \| C55H1.1 \| F10D2.8 \| F54C1.1 \| H23N18.4 \| K04A8.10 \| ugt-1 \| ugt-10 \| ugt-11 \| ugt-12 \| ugt-13 \| ugt-14 \| ugt-15 \| ugt-16 \| ugt-17 \| ugt-18 \| ugt-19 \| ugt-2 \| ugt-20 \| ugt-21 \| ugt-22 \| ugt-23 \| ugt-24 \| ugt-25 \| ugt-26 \| ugt-27 \| ugt-29 \| ugt-3 \| ugt-30 \| ugt-31 \| ugt-32 \| ugt-33 \| ugt-34 \| ugt-35 \| ugt-36 \| ugt-37 \| ugt-38 \| ugt-39 \| ugt-4 \| ugt-40 \| ugt-41 \| ugt-42 \| ugt-43 \| ugt-44 \| ugt-45 \| ugt-46 \| ugt-47 \| ugt-48 \| ugt-49 \| ugt-5 \| ugt-50 \| ugt-51 \| ugt-52 \| ugt-53 \| ugt-54 \| ugt-55 \| ugt-56 \| ugt-58 \| ugt-59 \| ugt-6 \| ugt-60 \| ugt-61 \| ugt-62 \| ugt-63 \| ugt-64 \| ugt-65 \| ugt-7 \| ugt-8 \| ugt-9	Miscellaneous
TCE5300Name: UDP-D-glucuronate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item[e]	udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item[c]	Not determined	Transport
EX00167Name: UDP-D-glucuronate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	udpglcurName: UDP-D-glucuronate Formula: C15H19N2O18P2 Charge: -3 click to see details on this item[e]		Not applicable	Exchange with the environment

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