Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	dhbpt
Name .....................................................	:	"6,7-Dihydrobiopterin", etc.Dihydrobiopterin, 6,7-Dihydrobiopterin, Quinoid-dihydrobiopterin, (6R)-6-(L-erythro-1,2-Dihydroxypropyl)-7,8-dihydro-6H-pterin
Model ID .....................................................	:	C00268
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00268
Formula .....................................................	:	C9H13N5O3
Charge .....................................................	:	0
Localization .....................................................	:	Extracellular, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	dhbpt
Other associations .....................................................	:	See reaction table below (11 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Represented in 5 maps... Ether lipid metabolism (c) Folate biosynthesis (c) Phenylalanine degradation (c) Tryptophan degradation (c) Tyrosine metabolism (c)   Go to map

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0140Name: glyceryl-ether monoxygenase Type: Regular Location: Cytosol KEGG ID: R04044 click to see details on this item	1.14.16.5Name: alkylglycerol monooxygenase Other names: glyceryl-ether monooxygenase, glyceryl-ether cleaving enzyme, glyceryl ether oxygenase, glyceryl etherase, O-alkylglycerol monooxygenase click to see details on this item	[c] : ak2lgcholName: 1-Alkyl-2-lyso-sn-glycero-3-phosphocholine Formula: C8H19NO6PRC2H4 Charge: 0 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		hak2lgcholName: 1-hydroxyalkyl-2-lyso-sn-glycero-3-phosphocholine Formula: C8H19NO6PRC2H4O Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	agmo-1	Ether lipid metabolism
RC01793Name: 5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01793 click to see details on this item	1.5.1.34Name: 6,7-dihydropteridine reductase Other names: 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase click to see details on this item	[c] : dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item	qdpr-1	Folate biosynthesis
RC01794Name: 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01794 click to see details on this item	1.5.1.34Name: 6,7-dihydropteridine reductase Other names: 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase click to see details on this item	[c] : dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item	qdpr-1	Folate biosynthesis
RC01795Name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Type: Regular Location: Cytosol KEGG ID: R01795 click to see details on this item	1.14.16.1Name: phenylalanine 4-monooxygenase Other names: phenylalaninase, phenylalanine 4-hydroxylase, phenylalanine hydroxylase click to see details on this item	[c] : o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + phe-LName: L-Phenylalanine Formula: C9H11NO2 Charge: 0 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item		dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + tyr-LName: L-Tyrosine Formula: C9H11NO3 Charge: 0 click to see details on this item	pah-1	Folate biosynthesis
RC04734Name: 4a-hydroxytetrahydrobiopterin hydro-lyase Type: Regular Location: Cytosol KEGG ID: R04734 click to see details on this item	4.2.1.96Name: 4a-hydroxytetrahydrobiopterin dehydratase Other names: 4alpha-hydroxy-tetrahydropterin dehydratase, pterin-4alpha-carbinolamine dehydratase, 4a-hydroxytetrahydrobiopterin hydro-lyase click to see details on this item	[c] : thbpt4acamName: Tetrahydrobiopterin-4a-carbinolamine Formula: C9H15N5O4 Charge: 0 click to see details on this item		dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	pcbd-1	Folate biosynthesis
RC01816Name: anthranilate 3-monooxygenase Type: Regular Location: Cytosol KEGG ID: R01816 click to see details on this item	1.14.16.3Name: anthranilate 3-monooxygenase Other names: anthranilate 3-hydroxylase, anthranilate hydroxylase, anthranilic hydroxylase, anthranilic acid hydroxylase click to see details on this item	[c] : thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + anthName: Anthranilate Formula: C7H6NO2 Charge: -1 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		3hanthrnName: 3-Hydroxyanthranilate Formula: C7H7NO3 Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	Unknown	Tryptophan degradation
RC01814Name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (Dihydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R01814 click to see details on this item	1.14.16.4Name: tryptophan 5-monooxygenase Other names: L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-hydroxylase, tryptophan hydroxylase click to see details on this item	[c] : thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + trp-LName: L-Tryptophan Formula: C11H12N2O2 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	tph-1	Folate biosynthesis
RC01815Name: L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) (Dihydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R01815 click to see details on this item	1.14.16.2Name: tyrosine 3-monooxygenase Other names: L-tyrosine hydroxylase, tyrosine 3-hydroxylase, tyrosine hydroxylase click to see details on this item	[c] : thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + tyr-LName: L-Tyrosine Formula: C9H11NO3 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		34dhpheName: "3,4-Dihydroxy-L-phenylalanine" Formula: C9H11NO4 Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	cat-2	Folate biosynthesis
DMN0048Name: dihydrobiopterin demand Type: Demand Location: Cytosol KEGG ID: NA click to see details on this item	Not applicable	dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item[c]			Not applicable	Demand reactions
TCE5325Name: 6,7-Dihydrobiopterin transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item[c]		dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item[e]	Not determined	Transport
EX00268Name: "6,7-Dihydrobiopterin" exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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