Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Pathway Overview

Name .....................................................	:	Tryptophan degradation
Related pathway (?) The pathway found in other databases to which this pathway is related. .....................................................	:	ERROR
Number of reactions .....................................................	:	19
In WormPaths (?) If the pathway is available as a WormPaths map you will find the name and link of map here. .....................................................	:	Tryptophan degradation

External links

Reactions (?) Click to see these reactions in the related KEGG pathway (only enzymes that are represented in kegg are highlighted).

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00685Name: L-Tryptophan decarboxy-lyase Type: Regular Location: Cytosol KEGG ID: R00685 click to see details on this item	4.1.1.28Name: aromatic-L-amino-acid decarboxylase Other names: DOPA decarboxylase, tryptophan decarboxylase, hydroxytryptophan decarboxylase, L-DOPA decarboxylase, aromatic amino acid decarboxylase, 5-hydroxytryptophan decarboxylase, aromatic-L-amino-acid carboxy-lyase (tryptamine-forming) click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + trp-LName: L-Tryptophan Formula: C11H12N2O2 Charge: 0 click to see details on this item		co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + tryptaName: Tryptamine Formula: C10H13N2 Charge: 1 click to see details on this item	bas-1 | hdl-1 | tdc-1	Tryptophan degradation
RC00678Name: L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) Type: Regular Location: Cytosol KEGG ID: R00678 click to see details on this item	1.13.11.11Name: tryptophan 2,3-dioxygenase Other names: tryptophan pyrrolase (ambiguous), tryptophanase, tryptophan oxygenase, tryptamine 2,3-dioxygenase, tryptophan peroxidase, indoleamine 2,3-dioxygenase (ambiguous), indolamine 2,3-dioxygenase (ambiguous), L-tryptophan pyrrolase, TDO, L-tryptophan 2,3-dioxygenase click to see details on this item	[c] : o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + trp-LName: L-Tryptophan Formula: C11H12N2O2 Charge: 0 click to see details on this item		LfmkynrName: L-Formylkynurenine Formula: C11H12N2O4 Charge: 0 click to see details on this item	tdo-2	Tryptophan degradation
RC01956Name: L-Kynurenine:2-oxoglutarate aminotransferase Type: Regular Location: Cytosol KEGG ID: R01956 click to see details on this item	2.6.1.7Name: kynurenine---oxoglutarate transaminase Other names: kynurenine transaminase (cyclizing), kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, L-kynurenine aminotransferase click to see details on this item	[c] : LkynrName: L-Kynurenine Formula: C10H12N2O3 Charge: 0 click to see details on this item + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item		4aphdobName: "4-(2-Aminophenyl)-2,4-dioxobutanoate" Formula: C10H8NO4 Charge: -1 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	nkat-1	Tryptophan degradation
RC04171Name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase Type: Regular Location: Cytosol KEGG ID: R04171 click to see details on this item	2.6.1.7Name: kynurenine---oxoglutarate transaminase Other names: kynurenine transaminase (cyclizing), kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, L-kynurenine aminotransferase click to see details on this item	[c] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + hLkynrName: 3-Hydroxy-L-kynurenine Formula: C10H12N2O4 Charge: 0 click to see details on this item		42A3HP24DBName: "4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate" Formula: C10H8NO5 Charge: -1 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	nkat-1	Tryptophan degradation
RC02670Name: Hydroxyanthranilate oxidation Type: Regular Location: Cytosol KEGG ID: R02670 click to see details on this item	1.11.1.6Name: catalase Other names: equilase, caperase, optidase, catalase-peroxidase, CAT click to see details on this item	[c] : (2) 3hanthrnName: 3-Hydroxyanthranilate Formula: C7H7NO3 Charge: 0 click to see details on this item + (4) o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		cinnavalininateName: Cinnavalininate Formula: C14H6N2O6 Charge: -2 click to see details on this item + (2) o2sName: Superoxide anion Formula: O2 Charge: -1 click to see details on this item + (2) h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item + (4) hName: H+ Formula: H Charge: 1 click to see details on this item	ctl-1 | ctl-2 | ctl-3	Tryptophan degradation
RC02665Name: 3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) Type: Regular Location: Cytosol KEGG ID: R02665 click to see details on this item	1.13.11.6Name: 3-hydroxyanthranilate 3,4-dioxygenase Other names: 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3-hydroxyanthranilic acid oxidase, 3HAO click to see details on this item	[c] : 3hanthrnName: 3-Hydroxyanthranilate Formula: C7H7NO3 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		cmusaName: 2-Amino-3-carboxymuconate semialdehyde Formula: C7H6NO5 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	haao-1	Tryptophan degradation
RC04293Name: Quinolinate synthase (eukaryotic) Type: Regular Location: Cytosol KEGG ID: R04293 click to see details on this item	spontaneous	[c] : cmusaName: 2-Amino-3-carboxymuconate semialdehyde Formula: C7H6NO5 Charge: -1 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + qulnName: Quinolinate Formula: C7H3NO4 Charge: -2 click to see details on this item	Not applicable	Tryptophan degradation
RC04323Name: 2-Amino-3-carboxymuconate semialdehyde carboxy-lyase Type: Regular Location: Cytosol KEGG ID: R04323 click to see details on this item	4.1.1.45Name: aminocarboxymuconate-semialdehyde decarboxylase Other names: picolinic acid carboxylase, picolinic acid decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase, 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase, 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase click to see details on this item	[c] : cmusaName: 2-Amino-3-carboxymuconate semialdehyde Formula: C7H6NO5 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		am6saName: 2-Aminomuconate 6-semialdehyde Formula: C6H7NO3 Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	acsd-1	Tryptophan degradation
RC01959Name: N-Formyl-L-kynurenine amidohydrolase Type: Regular Location: Cytosol KEGG ID: R01959 click to see details on this item	3.5.1.9Name: arylformamidase Other names: kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, formamidase II click to see details on this item	[c] : LfmkynrName: L-Formylkynurenine Formula: C11H12N2O4 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		LkynrName: L-Kynurenine Formula: C10H12N2O3 Charge: 0 click to see details on this item + forName: Formate Formula: CH1O2 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	afmd-1	Tryptophan degradation
RC00988Name: N-Formylanthranilate amidohydrolase Type: Regular Location: Cytosol KEGG ID: R00988 click to see details on this item	3.5.1.9Name: arylformamidase Other names: kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, formamidase II click to see details on this item	[c] : nformanthName: N-Formylanthranilate Formula: C8H6NO3 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		forName: Formate Formula: CH1O2 Charge: -1 click to see details on this item + anthName: Anthranilate Formula: C7H6NO2 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	afmd-1	Tryptophan degradation
RC03889Name: 2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase Type: Regular Location: Cytosol KEGG ID: R03889 click to see details on this item	1.2.1.32Name: aminomuconate-semialdehyde dehydrogenase Other names: 2-aminomuconate semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase click to see details on this item	[c] : am6saName: 2-Aminomuconate 6-semialdehyde Formula: C6H7NO3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		amucoName: 2-Aminomuconate Formula: C6H6NO4 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	To be determined	Tryptophan degradation
RC01938Name: 2-aminomuconate reductase Type: Regular Location: Cytosol KEGG ID: R01938 click to see details on this item	1.5.1.-Name: 2-aminomuconate reductase click to see details on this item	[c] : amucoName: 2-Aminomuconate Formula: C6H6NO4 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item	Unknown	Tryptophan degradation
RC01816Name: anthranilate 3-monooxygenase Type: Regular Location: Cytosol KEGG ID: R01816 click to see details on this item	1.14.16.3Name: anthranilate 3-monooxygenase Other names: anthranilate 3-hydroxylase, anthranilate hydroxylase, anthranilic hydroxylase, anthranilic acid hydroxylase click to see details on this item	[c] : thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + anthName: Anthranilate Formula: C7H6NO2 Charge: -1 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		3hanthrnName: 3-Hydroxyanthranilate Formula: C7H7NO3 Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	Unknown	Tryptophan degradation
RM02678Name: Indole-3-acetaldehyde:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R02678 click to see details on this item	1.2.1.3Name: aldehyde dehydrogenase (NAD+) Other names: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD) click to see details on this item	[m] : id3acaldName: Indole-3-acetaldehyde Formula: C10H9NO Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ind3acName: Indole-3-acetate Formula: C10H8NO2 Charge: -1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item	(alh-1 | alh-2 | alh-4) | alh-9	Tryptophan degradation
RC02678Name: Indole-3-acetaldehyde:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R02678 click to see details on this item	1.2.1.3Name: aldehyde dehydrogenase (NAD+) Other names: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD) click to see details on this item	[c] : id3acaldName: Indole-3-acetaldehyde Formula: C10H9NO Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ind3acName: Indole-3-acetate Formula: C10H8NO2 Charge: -1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item	(alh-2 | alh-4) | (alh-11 | alh-12)	Tryptophan degradation
RC04903Name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R04903 click to see details on this item	1.2.1.3Name: aldehyde dehydrogenase (NAD+) Other names: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD) click to see details on this item	[c] : 5hoxindactName: 5-Hydroxyindoleacetaldehyde Formula: C10H9NO2 Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		5hoxindoaName: 5-Hydroxyindoleacetate Formula: C10H8NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	(alh-2 | alh-4) | (alh-11 | alh-12)	Tryptophan degradation
RC02173Name: Tryptamine:oxygen oxidoreductase (deaminating) Type: Regular Location: Cytosol KEGG ID: R02173 click to see details on this item	1.4.3.4Name: monoamine oxidase Other names: adrenalin oxidase, adrenaline oxidase, amine oxidase (ambiguous), amine oxidase (flavin-containing), amine:oxygen oxidoreductase (deaminating) (flavin-containing), epinephrine oxidase, MAO, MAO A, MAO B, MAO-A, MAO-B, monoamine oxidase A, monoamine oxidase B, monoamine:O2 oxidoreductase (deaminating), polyamine oxidase (ambiguous), serotonin deaminase, spermidine oxidase (ambiguous), spermine oxidase (ambiguous), tyraminase, tyramine oxidase click to see details on this item	[c] : tryptaName: Tryptamine Formula: C10H13N2 Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		id3acaldName: Indole-3-acetaldehyde Formula: C10H9NO Charge: 0 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item + h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item	amx-2	Tryptophan degradation
RC02908Name: 5-Hydroxytryptamine:oxygen oxidoreductase (deaminating) (flavin-containing) Type: Regular Location: Cytosol KEGG ID: R02908 click to see details on this item	1.4.3.4Name: monoamine oxidase Other names: adrenalin oxidase, adrenaline oxidase, amine oxidase (ambiguous), amine oxidase (flavin-containing), amine:oxygen oxidoreductase (deaminating) (flavin-containing), epinephrine oxidase, MAO, MAO A, MAO B, MAO-A, MAO-B, monoamine oxidase A, monoamine oxidase B, monoamine:O2 oxidoreductase (deaminating), polyamine oxidase (ambiguous), serotonin deaminase, spermidine oxidase (ambiguous), spermine oxidase (ambiguous), tyraminase, tyramine oxidase click to see details on this item	[c] : srtnName: Serotonin Formula: C10H13N2O Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		5hoxindactName: 5-Hydroxyindoleacetaldehyde Formula: C10H9NO2 Charge: 0 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item + h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item	amx-2	Tryptophan degradation
RC02701Name: 5-Hydroxy-L-tryptophan decarboxy-lyase Type: Regular Location: Cytosol KEGG ID: R02701 click to see details on this item	4.1.1.28Name: aromatic-L-amino-acid decarboxylase Other names: DOPA decarboxylase, tryptophan decarboxylase, hydroxytryptophan decarboxylase, L-DOPA decarboxylase, aromatic amino acid decarboxylase, 5-hydroxytryptophan decarboxylase, aromatic-L-amino-acid carboxy-lyase (tryptamine-forming) click to see details on this item	[c] : 5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		srtnName: Serotonin Formula: C10H13N2O Charge: 1 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	bas-1	Tryptophan degradation

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