Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	2hglut
Name .....................................................	:	(S)-2-Hydroxyglutarate, etc.2-Hydroxyglutarate, alpha-Hydroxyglutarate
Model ID .....................................................	:	C02630
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C02630
Formula .....................................................	:	C5H6O5
Charge .....................................................	:	-2
Localization .....................................................	:	Extracellular, Cytosol, Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	S2hglut
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Ketone body metabolism (m), Propionate degradation (m)

iCEL1314

Comments

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM03534Name: 2-Hydroxyglutarate:(acceptor) 2-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03534;R10575 click to see details on this item	1.1.99.2Name: L-2-hydroxyglutarate dehydrogenase Other names: alpha-ketoglutarate reductase, alpha-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate dehydrogenase, hydroxyglutaric dehydrogenase, alpha-hydroxyglutarate oxidoreductase, L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase, alpha-hydroxyglutarate dehydrogenase (NAD+ specific), (S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase click to see details on this item 1.1.99.39Name: D-2-hydroxyglutarate dehydrogenase Other names: AtD-2HGDH click to see details on this item	[m] : 2hglutName: (S)-2-Hydroxyglutarate Formula: C5H6O5 Charge: -2 click to see details on this item + fadName: Flavin adenine dinucleotide oxidized Formula: C27H31N9O15P2 Charge: -2 click to see details on this item		akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + fadh2Name: Flavin adenine dinucleotide reduced Formula: C27H33N9O15P2 Charge: -2 click to see details on this item	Y45G12B.3 | F54D5.12	Miscellaneous
RC08198Name: alphaKG reductase Type: Regular Location: Cytosol KEGG ID: R08198 click to see details on this item	1.1.1.95Name: phosphoglycerate dehydrogenase Other names: D-3-phosphoglycerate:NAD+ oxidoreductase, alpha-phosphoglycerate dehydrogenase, 3-phosphoglycerate dehydrogenase, 3-phosphoglyceric acid dehydrogenase, D-3-phosphoglycerate dehydrogenase, glycerate 3-phosphate dehydrogenase, glycerate-1,3-phosphate dehydrogenase, phosphoglycerate oxidoreductase, phosphoglyceric acid dehydrogenase, SerA, 3-phosphoglycerate:NAD+ 2-oxidoreductase, SerA 3PG dehydrogenase, 3PHP reductase, alphaKG reductase, D- and L-HGA click to see details on this item	[c] : 2hglutName: (S)-2-Hydroxyglutarate Formula: C5H6O5 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	C31C9.2	Miscellaneous
RM03225Name: (S)-3-Hydroxybutanoate:2-oxoglutarate oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03225 click to see details on this item	1.1.99.24Name: hydroxyacid-oxoacid transhydrogenase Other names: transhydrogenase, hydroxy acid-oxo acid click to see details on this item	[m] : S3hbName: (S)-3-Hydroxybutanoate Formula: C4H7O3 Charge: -1 click to see details on this item + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + 2hglutName: (S)-2-Hydroxyglutarate Formula: C5H6O5 Charge: -2 click to see details on this item	hphd-1	Ketone body metabolism
TCE5021Name: 2-hydroxyglutarate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	2hglutName: (S)-2-Hydroxyglutarate Formula: C5H6O5 Charge: -2 click to see details on this item[c]		2hglutName: (S)-2-Hydroxyglutarate Formula: C5H6O5 Charge: -2 click to see details on this item[e]	To be determined	Transport
EX02630Name: 2-hydroxyglutarate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	2hglutName: (S)-2-Hydroxyglutarate Formula: C5H6O5 Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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