Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	5thf
Name .....................................................	:	pentaglutamyl folate (THF)
Model ID .....................................................	:	CC0004
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	Not available
Formula .....................................................	:	C39H45N11O18
Charge .....................................................	:	-6
Localization .....................................................	:	Cytosol, Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	5thf
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Folate cycle (m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RMC0023Name: Tetrahydrofolyl-[Glu](n):L-glutamate gamma-ligase (ADP-forming) (producing 5thf) Type: Regular Location: Mitochondria KEGG ID: R04241;R00942 click to see details on this item	6.3.2.17Name: tetrahydrofolate synthase Other names: folylpolyglutamate synthase, folate polyglutamate synthetase, formyltetrahydropteroyldiglutamate synthetase, N10-formyltetrahydropteroyldiglutamate synthetase, folylpoly-gamma-glutamate synthase, folylpolyglutamyl synthetase, folylpoly(gamma-glutamate) synthase, folylpolyglutamate synthetase, folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, FPGS, tetrahydrofolylpolyglutamate synthase, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) click to see details on this item	[m] : (4) atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + (4) glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate" Formula: C19H21N7O6 Charge: -2 click to see details on this item		5thfName: pentaglutamyl folate (THF) Formula: C39H45N11O18 Charge: -6 click to see details on this item + (4) adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + (4) hName: H+ Formula: H Charge: 1 click to see details on this item + (4) piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	F25B5.6	Folate cycle
RMC0024Name: Tetrahydrofolyl-[Glu](n):L-glutamate gamma-ligase (ADP-forming) (producing 7thf) Type: Regular Location: Mitochondria KEGG ID: R04241;R00942 click to see details on this item	6.3.2.17Name: tetrahydrofolate synthase Other names: folylpolyglutamate synthase, folate polyglutamate synthetase, formyltetrahydropteroyldiglutamate synthetase, N10-formyltetrahydropteroyldiglutamate synthetase, folylpoly-gamma-glutamate synthase, folylpolyglutamyl synthetase, folylpoly(gamma-glutamate) synthase, folylpolyglutamate synthetase, folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, FPGS, tetrahydrofolylpolyglutamate synthase, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) click to see details on this item	[m] : (2) atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + (2) glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + 5thfName: pentaglutamyl folate (THF) Formula: C39H45N11O18 Charge: -6 click to see details on this item		7thfName: heptaglutamyl folate (THF) Formula: C49H57N13O24 Charge: -8 click to see details on this item + (2) adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + (2) piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	F25B5.6	Folate cycle
TCM0084Name: pentaglutamyl folate (THF) transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	5thfName: pentaglutamyl folate (THF) Formula: C39H45N11O18 Charge: -6 click to see details on this item[m]		5thfName: pentaglutamyl folate (THF) Formula: C39H45N11O18 Charge: -6 click to see details on this item[c]	Not determined	Transport

The information and tools provided in this website are to be used for academic purposes only. Potential users of the flux analysis tools (FBA button in the vertical menu) are asked to show proof of working at an academic institution during the creation of their accounts. These mathematical tools are powered by the commercial software Gurobi.