Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	4hpro-LT
Name .....................................................	:	trans-4-Hydroxy-L-proline, etc.Hydroxyproline, L-Hydroxyproline
Model ID .....................................................	:	C01157
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C01157
Formula .....................................................	:	C5H9NO3
Charge .....................................................	:	0
Localization .....................................................	:	Cytosol, Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	4hpro-LT
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Proline metabolism (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC01252Name: L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) Type: Regular Location: Cytosol KEGG ID: R01252 click to see details on this item	1.14.11.2Name: procollagen-proline dioxygenase Other names: protocollagen hydroxylase, proline hydroxylase, proline,2-oxoglutarate 4-dioxygenase, collagen proline hydroxylase, hydroxylase, collagen proline, peptidyl proline hydroxylase, proline protocollagen hydroxylase, proline, 2-oxoglutarate dioxygenase, prolyl hydroxylase, prolylprotocollagen dioxygenase, prolylprotocollagen hydroxylase, protocollagen proline 4-hydroxylase, protocollagen proline dioxygenase, protocollagen proline hydroxylase, protocollagen prolyl hydroxylase, prolyl 4-hydroxylase, prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating, procollagen-proline 4-dioxygenase click to see details on this item	[c] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + pro-LName: L-Proline Formula: C5H9NO2 Charge: 0 click to see details on this item		4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item	C14E2.4 | Y43F8B.19 | dpy-18 | phy-2 | phy-3 | phy-4	Proline metabolism
RM03291Name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03291 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		1p3h5cName: L-1-Pyrroline-3-hydroxy-5-carboxylate Formula: C5H6NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	M153.1 | F55G1.9	Proline metabolism
RM03293Name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03293 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		1p3h5cName: L-1-Pyrroline-3-hydroxy-5-carboxylate Formula: C5H6NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	M153.1 | F55G1.9	Proline metabolism
TCM1078Name: trans-4-Hydroxy-L-proline transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item[c]		4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item[m]	Not determined	Transport

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