Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Pathway Overview

Name .....................................................	:	Proline metabolism
Related pathway (?) The pathway found in other databases to which this pathway is related. .....................................................	:	ERROR
Number of reactions .....................................................	:	11
In WormPaths (?) If the pathway is available as a WormPaths map you will find the name and link of map here. .....................................................	:	Proline metabolism

External links

Reactions (?) Click to see these reactions in the related KEGG pathway (only enzymes that are represented in kegg are highlighted).

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01248Name: L-Proline:NAD+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R01248 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 1pyr5cName: 1-Pyrroline-5-carboxylate Formula: C5H6NO2 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + pro-LName: L-Proline Formula: C5H9NO2 Charge: 0 click to see details on this item	M153.1 | F55G1.9	Proline metabolism
RM01253Name: L-proline:(acceptor) oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R10507 click to see details on this item	1.5.-.-Name: l-proline:(acceptor) oxidoreductase click to see details on this item	[m] : fadName: Flavin adenine dinucleotide oxidized Formula: C27H31N9O15P2 Charge: -2 click to see details on this item + pro-LName: L-Proline Formula: C5H9NO2 Charge: 0 click to see details on this item		1pyr5cName: 1-Pyrroline-5-carboxylate Formula: C5H6NO2 Charge: -1 click to see details on this item + fadh2Name: Flavin adenine dinucleotide reduced Formula: C27H33N9O15P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	B0513.5	Proline metabolism
RC01252Name: L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) Type: Regular Location: Cytosol KEGG ID: R01252 click to see details on this item	1.14.11.2Name: procollagen-proline dioxygenase Other names: protocollagen hydroxylase, proline hydroxylase, proline,2-oxoglutarate 4-dioxygenase, collagen proline hydroxylase, hydroxylase, collagen proline, peptidyl proline hydroxylase, proline protocollagen hydroxylase, proline, 2-oxoglutarate dioxygenase, prolyl hydroxylase, prolylprotocollagen dioxygenase, prolylprotocollagen hydroxylase, protocollagen proline 4-hydroxylase, protocollagen proline dioxygenase, protocollagen proline hydroxylase, protocollagen prolyl hydroxylase, prolyl 4-hydroxylase, prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating, procollagen-proline 4-dioxygenase click to see details on this item	[c] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + pro-LName: L-Proline Formula: C5H9NO2 Charge: 0 click to see details on this item		4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item	C14E2.4 | Y43F8B.19 | dpy-18 | phy-2 | phy-3 | phy-4	Proline metabolism
RM03291Name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03291 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		1p3h5cName: L-1-Pyrroline-3-hydroxy-5-carboxylate Formula: C5H6NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	M153.1 | F55G1.9	Proline metabolism
RM03293Name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03293 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		1p3h5cName: L-1-Pyrroline-3-hydroxy-5-carboxylate Formula: C5H6NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	M153.1 | F55G1.9	Proline metabolism
RM05051Name: L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R05051 click to see details on this item	1.2.1.88Name: L-glutamate gamma-semialdehyde dehydrogenase Other names: 1-pyrroline-5-carboxylate dehydrogenase, Delta1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase, Delta1-pyrroline-5-carboxylic acid dehydrogenase click to see details on this item	[m] : 4hglusaName: L-4-Hydroxyglutamate semialdehyde Formula: C5H9NO4 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	alh-6	Proline metabolism
RMC0016Name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial Type: Regular Location: Mitochondria KEGG ID: NA click to see details on this item	spontaneous	[m] : 1p3h5cName: L-1-Pyrroline-3-hydroxy-5-carboxylate Formula: C5H6NO3 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		4hglusaName: L-4-Hydroxyglutamate semialdehyde Formula: C5H9NO4 Charge: 0 click to see details on this item	Not applicable	Proline metabolism
RM05052Name: L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R05052 click to see details on this item	2.6.1.1Name: aspartate transaminase Other names: glutamic-oxaloacetic transaminase, glutamic-aspartic transaminase, transaminase A, AAT, AspT, 2-oxoglutarate-glutamate aminotransferase, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AST, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamic-aspartic aminotransferase, glutamic-oxalacetic transaminase, glutamic oxalic transaminase, GOT (enzyme) [ambiguous], L-aspartate transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartic aminotransferase, oxaloacetate-aspartate aminotransferase, oxaloacetate transferase, aspartate:2-oxoglutarate aminotransferase, glutamate oxaloacetate transaminase click to see details on this item	[m] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item		4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	got-2.1 | got-2.2	Proline metabolism
RC05052Name: L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase Type: Regular Location: Cytosol KEGG ID: R05052 click to see details on this item	2.6.1.1Name: aspartate transaminase Other names: glutamic-oxaloacetic transaminase, glutamic-aspartic transaminase, transaminase A, AAT, AspT, 2-oxoglutarate-glutamate aminotransferase, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AST, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamic-aspartic aminotransferase, glutamic-oxalacetic transaminase, glutamic oxalic transaminase, GOT (enzyme) [ambiguous], L-aspartate transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartic aminotransferase, oxaloacetate-aspartate aminotransferase, oxaloacetate transferase, aspartate:2-oxoglutarate aminotransferase, glutamate oxaloacetate transaminase click to see details on this item	[c] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item		4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	got-1.2	Proline metabolism
RM00471Name: D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase Type: Regular Location: Mitochondria KEGG ID: R00471 click to see details on this item	4.1.3.16Name: 4-hydroxy-2-oxoglutarate aldolase Other names: 2-oxo-4-hydroxyglutarate aldolase, hydroxyketoglutaric aldolase, 4-hydroxy-2-ketoglutaric aldolase, 2-keto-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, DL-4-hydroxy-2-ketoglutarate aldolase, hydroxyketoglutarate aldolase, 2-keto-4-hydroxybutyrate aldolase, 4-hydroxy-2-oxoglutarate glyoxylate-lyase, KHGA click to see details on this item	[m] : 4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item		glxName: Glyoxylate Formula: C2H1O3 Charge: -1 click to see details on this item + pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item	Unknown	Proline metabolism
RC00471Name: D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase Type: Regular Location: Cytosol KEGG ID: R00471 click to see details on this item	4.1.3.16Name: 4-hydroxy-2-oxoglutarate aldolase Other names: 2-oxo-4-hydroxyglutarate aldolase, hydroxyketoglutaric aldolase, 4-hydroxy-2-ketoglutaric aldolase, 2-keto-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, DL-4-hydroxy-2-ketoglutarate aldolase, hydroxyketoglutarate aldolase, 2-keto-4-hydroxybutyrate aldolase, 4-hydroxy-2-oxoglutarate glyoxylate-lyase, KHGA click to see details on this item	[c] : 4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item		glxName: Glyoxylate Formula: C2H1O3 Charge: -1 click to see details on this item + pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item	Unknown	Proline metabolism

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