Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

Metabolite Overview

Abbreviation .....................................................	:	2oxoadp
Name .....................................................	:	2-Oxoadipate, etc.2-Oxoadipic acid
Model ID .....................................................	:	C00322
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00322
Formula .....................................................	:	C6H6O5
Charge .....................................................	:	-2
Localization .....................................................	:	Extracellular, Cytosol, Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	2oxoadp
Other associations .....................................................	:	See reaction table below (7 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Glutamate / glutamine metabolism (c,m), Lysine degradation (m), Tryptophan degradation (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RMC0014Name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating); Glutaryl-CoA:dihydrolipoamide S-succinyltransferase; Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+ Type: Regular Location: Mitochondria KEGG ID: R01940;R02571;R07618 click to see details on this item	1.2.4.2Name: oxoglutarate dehydrogenase (succinyl-transferring) Other names: 2-ketoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase, 2-oxoglutarate: lipoate oxidoreductase, 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating), alpha-ketoglutarate dehydrogenase, alphaketoglutaric acid dehydrogenase, alpha-ketoglutaric dehydrogenase, alpha-oxoglutarate dehydrogenase, AKGDH, OGDC, ketoglutaric dehydrogenase, oxoglutarate decarboxylase, oxoglutarate dehydrogenase, oxoglutarate dehydrogenase (lipoamide) click to see details on this item 2.3.1.61Name: dihydrolipoyllysine-residue succinyltransferase Other names: dihydrolipoamide S-succinyltransferase, dihydrolipoamide succinyltransferase, dihydrolipoic transsuccinylase, dihydrolipolyl transsuccinylase, dihydrolipoyl transsuccinylase, lipoate succinyltransferase (Escherichia coli), lipoic transsuccinylase, lipoyl transsuccinylase, succinyl-CoA:dihydrolipoamide S-succinyltransferase, succinyl-CoA:dihydrolipoate S-succinyltransferase, enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase click to see details on this item 1.8.1.4Name: dihydrolipoyl dehydrogenase Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase click to see details on this item	[m] : 2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + glutcoaName: Glutaryl-CoA Formula: C26H37N7O19P3S Charge: -5 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	(ogdh-1 & ogdh-2) & dlst-1 & dld-1	Lysine degradation
RM01939Name: L-2-aminoadipate:2-oxoglutarate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R01939 click to see details on this item	2.6.1.39Name: 2-aminoadipate transaminase Other names: alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, glutamic-ketoadipic transaminase, glutamate-alpha-ketoadipate transaminase click to see details on this item	[m] : L2aadpName: L-2-Aminoadipate Formula: C6H10NO4 Charge: -1 click to see details on this item + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item		2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	To be determined	Lysine degradation
RC01938Name: 2-aminomuconate reductase Type: Regular Location: Cytosol KEGG ID: R01938 click to see details on this item	1.5.1.-Name: 2-aminomuconate reductase click to see details on this item	[c] : amucoName: 2-Aminomuconate Formula: C6H6NO4 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item	Unknown	Tryptophan degradation
TCM5510Name: 2-oxoadipate shuttle (cytosol/mitochondria) Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item[c] + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item[m]		2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item[m] + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCE5347Name: 2-Oxoadipate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item[c] + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item[e]		2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item[e] + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM1073Name: 2-Oxoadipate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item[m]		2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item[c]	Not determined	Transport
EX00322Name: 2-Oxoadipate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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